To inhibit human CYP3A4 and P-glycoprotein, enzymes for the metabolism and transport of xenobiotics and metabolites importantly.

In animal studies, piperine also inhibited other enzymes in drug metabolism importantly.

By inhibiting drug metabolism, piperine may increase the bioavailability of various compounds.

Piperine may enhance bioavailability of curcumin by 2000% in humans.